This interview is part of a series of interviews of the “Women in Research” blog that features young female scientists participating in the 68th Lindau Nobel Laureate Meeting to increase the visibility of women in research (more information for and about women in science by “Women in Research” on Facebook and Twitter).
#LINO18 young scientist Rushita Bagchi, 35, from India, is a Postdoctoral Research Fellow at the University of Colorado Denver, USA.
Her research involves elucidating epigenetic mechanisms that govern the pathogenesis of obesity and diabetes contributing to cardiometabolic syndrome. This work has great translational impact for development of therapeutics for treatment of obesity and diabetes (T2D).
What inspired you to pursue a career in science?
I have always been fascinated by the mysteries of nature and how scientific research helps unfold those in different ways. Curiosity has been my primary motivation for the pursuit of science in school and as a career choice. I always had an aptitude for biology, which formed the foundation of my continued interest in understanding physiological processes. Fortunately, I have had great mentors throughout my life who have inspired me to garner knowledge in various ways, and therefore helped me prepare to embark on this journey towards a career in biomedical research. The elements of challenge and surprise and my intrinsic curiosity continue to fuel my passion for science and research.
Who are your role models?
My parents have been my first and foremost role models. And I cannot express my gratitude in words for their unconditional love and encouragement.
When it comes to being influenced by ideals in science, I have been extremely fortunate to have had excellent mentors at every stage of my academic pursuit. Beginning with my teachers in grade school and professors in India, to my PhD and postdoctoral supervisors- each of them has had unique traits or skills that I have fancied of embodying someday. On a broader scale, I have been always in awe of the late Nobel Laureate Oliver Smithies for his simplicity and humble approach towards such an illustrious career in science. I had the opportunity of meeting him in person, and listen to him about his journey to the Nobel Prize. Being a woman in science myself, I have always found positive reinforcement looking up to women like the late Barbara McClintock who received the Nobel prize in 1983 for her pioneering work in the field of cytogenetics. She was born in a family with lesser privileges, but overcame all obstacles to pursue her dream and devoted her entire life to research. Two other female scientists that I admire for their relentlessness are Christiane Nüsslein-Volhard and Elizabeth Blackburn. I continue to be inspired by these women even today.
How did you get to where you are in your career path?
While pursuing my undergraduate degree in zoology in India, I realised that my longing to learn was growing by leaps and bounds. To satisfy my curiosity and eagerness to learn more about physiology and allied sciences, I went on to do a master’s degree as well. Throughout both these degree programmes, I was blessed to have some extremely supportive mentors who always pushed me to set and achieve higher goals. My academic pursuit was put on hold for a short time due to personal reasons. But soon enough, thanks to my ever supportive husband, I was able to successfully enroll in the PhD program at the University of Manitoba in Canada. Dr. Michael Czubryt as my Ph.D. supervisor taught me valuable life skills, and most importantly to believe in myself. I began to understand and appreciate the intricacies of scientific research under his tutelage, and that continues even today in my postdoctoral training program at the University of Colorado Denver. My doctoral degree training taught me to be diligent, organized, critical and think independently. After successful completion of my PhD program, I moved to Colorado, USA to pursue my postdoctoral training under the supervision of Dr. Timothy McKinsey. My training in his lab so far has taught me to be fearless in doing the groundwork and pursuing novel research ideas. I am hoping that what I have learned from my mentors will help propel my career in biomedical research.
What is the coolest project you have worked on and why?
Every project that I have worked on till date had its own defining moments. Being able to elucidate the novel role of a transcription factor in regulation of fibroblast function in the heart was an exciting and “cool” project during my PhD program. Successful completion of complex experiments in this project gave tremendous satisfaction. One of my postdoctoral research projects investigates the previously unknown role of a chromatin modifying enzyme in metabolic disease. This is a very exciting and yet another “cool” project to work on as this has great translational potential.
What’s a time you felt immense pride in yourself or your work?
It is difficult to define a particular time when I have felt immense pride in myself and my work. The best rewards and proudest moments for me have been the recognition that I have received for my work in the form of opportunities to present my work at international meetings and grant support received from national funding agencies. Although, I must say that it is a matter of immense pride in being the first ever successful nominee from the University of Manitoba to attend the Lindau Nobel Laureate Meeting. I was selected through a national research competition for graduate students in Canada, and secured the top spot to earn the nomination.
What is a “day in the life” of like?
My usual day starts early at 6 am when I wake up and take time to go through my emails and newly published articles or perspectives in my field of research. Sometimes before heading to work, I try to spend some time catching up with the rest of the world on social media or doing data analysis. It is pretty much time to hit the ground running as soon as I reach the lab. Around noon would be time for lunch with colleagues from my and other labs in the division. Early afternoon, I take a little time to catch up on emails before returning to the bench again to wrap up experiments for the day by the evening. Most evenings are long, but I attempt to plan out next day’s work in advance to save time the following day. I am usually back home by 8pm, when I prepare and have supper. Before bedtime, which is conventionally around midnight, I read articles or reviews to keep myself updated about research topics of interest.
What are you seeking to accomplish in your career?
As a young scientist in training now, I aspire to transition to the next step in my career as an independent investigator in recent future. Leading a research laboratory focused on studying mechanism of pathogenesis of cardiometabolic disease, I hope to contribute to the biomedical community through development of novel therapeutic strategies to treat patients suffering from debilitating conditions such as diabetes and heart failure. I am also committed towards training the next generation of biomedical researchers when I embark on my journey as an independent scientist.
What do you like to do when you’re not doing research?
Music is food for my soul, and culinary adventures teach me the art of experimentation. When I am not in the lab, I listen to relaxing classical music and am deeply investing my energy in creating my culinary “masterpieces” in the kitchen. Being able to create a unique dish in the kitchen somehow brings me the same joy and satisfaction that I would get from the successful completion of a complex experiment at the bench.
What advice do you have for other women interested in science?
Patience and perseverance is what will propel women in the sciences. One needs to find mentors who support women in science- it does get very lonely out there. It is important to create your own network which comprises colleagues, peers, and role models who are committed to helping one succeed even in the face of obstacles. Nothing is impossible to attain once you set your mind to it.
In your opinion, what will be the next great breakthrough in physiology or medicine?
With the current trend in use of gene editing technologies, especially the CRISPR-Cas system, we are not far from seeing the use of this tool in its current or improvised form in the clinic to treat patients harboring rare life-threatening genome mutations. Our knowledge of drug discovery tools and platforms has grown tremendously in the past few years, and this will pave the foundation for the emergence of novel and highly efficacious therapeutics for treatment of difficult to treat pathologies.
What should be done to increase the number of female scientists and female professors?
Opportunities and incentives to be retained in research should be increased for women. More women go to school and complete their degree programs successfully now than ever before. But not all of them find themselves in careers in science long-term. Individuals in higher seats of administration and policy makers are the ones who can truly effect a change in the system and help retain women as scientists and professors in the workforce. It is high time that gender equity, whether it comes to opportunities or pay scale, becomes a priority in our societies beyond political and social boundaries. Women need to support and mentor women, but so do men.