The Lindau mediatheque’s new Nobel Lab 360° of 2012 Chemistry Laureate Brian Kobilka introduces you to the biochemical and biophysical techniques applied to the study of molecular mechanisms of receptor signaling. You will encounter captivating film and audio settings as well as go on a fascinating journey of adrenaline molecule signaling pathways, demonstrating the complex processes of signal transduction pathways involved in cell signaling.
Click HERE to access Brian Kobilka’s Nobel Lab 360°
Brian Kobilka shared the 2012 Nobel Prize in Chemistry with Robert Lefkowitz for studies of G-protein coupled receptors. G-protein coupled receptors (GPCRs) are notably versatile signaling molecules. The majority of hormones and neurotransmitters, that transmit information within the body, are detected by G-protein coupled receptors. GPCRs have sensory functions, mediating olfaction, taste, light perception, hormone and pheromone signaling. When the external signaling molecule (ligand) binds to a receptor, the intracellular structure of the GPCR changes (conformational change) which activates the attached G-protein. The G-protein, a three component signaling protein coupled to the receptor inside the cell, then releases components that trigger particular cellular mechanisms. G-protein coupled receptors (GPCRs) build the largest family of cell surface receptors and represent the main target of drug development in the pharmaceutical industry.
Visit Brian Kobilka’s Nobel Lab 360° to learn about the techniques and methods necessary for membrane protein structure research and protein dynamics.