Published 30 June 2011 by Beatrice Lugger

Roger Y. Tsien – Lindau Nobel Laureate Meeting 201

Engineering Molecules for Fun, Profit, and Clinical Relevance


Molecules to observe and manipulate biological systems and disease processes can be devised by a variety of strategies, ranging from pure chemical design and total synthesis to genome mining and high-throughput directed evolution. Examples of both successes and failures will be chosen from my own experience, including calcium indicators, molecular voltmeters and photomultipliers, fluorescent proteins, and peptides that light up tumors and nerves. The key personal challenge is to match one’s own neuroses and pleasures with research challenges that will have the widest possible impact.

Beatrice Lugger

Beatrice Lugger is a science journalist and science social media specialist with a background as a chemist. She is Scientific Director of the National Institute for Science Communication, NaWik – @BLugger is her twitter handle, Quantensprung her own blog.